Manchester United are back in their "natural habitat" in the Champions League and are up for the challenge of playing against the best teams in Europe, manager Jose Mourinho said.
United had failed to qualify for the Champions League for Mourinho's debut campaign but their Europa League triumph last season secured a return to Europe's elite competition.
"Being back in the Champions League is going back to the natural habitat. Manchester United (have been there) season after season," Mourinho said.
"Motivation is very high.
"We have to try to go to the last 16 and enjoy that special knock-out phase with the best teams in Europe."
Defenders Eric Bailly and Phil Jones are serving suspensions and will be replaced by Chris Smalling and Victor Lindelof at the centre of defence for Tuesday's game, while midfielder Marouane Fellaini is a doubt as he recovers from a calf injury.
Smalling and Lindelof, United's close season signing from Benfica, will pair up for the first time since United's 2-1 defeat to Real Madrid in the UEFA Super Cup last month.
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