Andreas Christensen, Gary Cahill, Davide Zappacotta, Willian and Michy Batshuayi all come into the starting XI.
Cahill, who suspended against the Foxes, skippers the side while deadline-day signing Zappacosta makes his full debut.
David Luiz, Antonio Rudiger, Victor Moses, Tiemoue Bakayoko and Alvaro Morata drop out.
Eden Hazard has to contend with a place on the bench as he builds up his fitness.
Chelsea: Courtois; Azpilicueta, Christensen, Cahill (c); Zappacosta, Kante, Fabregas, Alonso; Willian, Batshuayi, Pedro
Subs: Caballero, Rudiger, Luiz, Moses, Bakayoko, Hazard, Morata
Qarabag: Sehic, Medvedev, Sadiqov, Huseynov, Rzezniczak, Qarayev, Almeida de Oliveira, Guerrier, Marcos Madera, Konzen Medina da Silva, Ndlovu
Subs: Kanibolotskiy, Amirquliyev, Madatov, Elyounoussi, Ismayilov, Yunuszada, Diniyev
