The Gunners will be looking to claim a Premier League point at Stamford Bridge for the first time since 2011.
They are coming up against a Chelsea side that have won three games on the bounce since their opening day defeat at home to Burnley, which included wins over Tottenham, Everton and Leicester.
But which players make a combined team from the two London clubs?
Ex-Everton midfielder Leon Osman picked his ultimate Chelsea and Arsenal XI for Sky Sports, with one position even proving too difficult to choose.
CLICK THROUGH THE GALLERY ABOVE TO SEE LEON OSMAN’S COMBINED CHELSEA AND ARSENAL XI.
