Manchester United will be desperate for a win after failing to win any of their last three games.
Jose Mourinho has seen his side draw against Leicester City and Burnley in the Premier League, whilst they were also knocked out of the Carabao Cup by Bristol City.
Manchester City may be out of sight, but Man United now have to worry about teams like Chelsea, Liverpool and Tottenham who are not far behind them.
Southampton suffered a disappointing 5-2 defeat against Tottenham on Boxing Day and they currently sit in 14th place, just two points above the relegation zone.
When the two sides met earlier in the season, just a single Romelu Lukaku goal seperated the two sides.
When is Manchester United v Southampton?
The match is on Saturday December 30th with kick-off at 17:30.
What TV channel is Manchester United v Southampton on?
The game will be shown live on BT Sport 1 from 17:00.
What are the odds? (Courtesy of William Hill)
Manchester United – 4/11
Draw – 19/5
Southampton – 7/1
Head-to-head in last five meetings
23 Sep 2017 – Premier League
Southampton 0-1 Manchester United
13 May 2017 – Premier League
Southampton 0-0 Manchester United
26 Feb 2017 – League Cup
Manchester United 3-2 Southampton
19 Aug 2016 – Premier League
Manchester United 2-0 Southampton
23 Jan 2016 – Premier League
Manchester United 0-1 Southampton
MORE : Jesse Lingard explains what Manchester United required to beat Burnley on Boxing Day
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