The five Premier League teams taking place in this season's Champions League have discovered their fixtures, and Manchester United have been handed a huge derby advantage.
Before the Red Devils host Manchester City at Old Trafford on the weekend of December 9, they'll have played a home match against CSKA Moscow on Tuesday, December 5.
Manchester City, however, will have faced a gruelling 3,500-mile round trip to Donetsk to play Shakhtar on the following day.
The news will hardly have been received well by City boss Pep Guardiola, as the English clubs found out their Champions League fate on Thursday .
United face a home game with Crystal Palace after their longest trip to Moscow to face CSKA on September 27.
Liverpool also go to Moscow that same week - potentially creating travel issues for both clubs' fans - with that fixture coming in the midle of a week on the road that'll see Liverpool also go to Leicester and Newcastle.
Chelsea will have to go to Anfield after a long trek to Azerbaijan to face Qarabag, while Spurs face a tough schedule as they take on Manchester United and Arsenal immediately after group games against Real Madrid and Borussia Dortmund.
The full list of fixtures and the Premier League games coming before and after them is below.
Chelsea
12 Sept: Qarabag (H) - Before: Leicester (A), After: Arsenal (H)
27 Sept: Atletico (A) - Before: Stoke (A), After: Manchester City (H)
18 Oct: Roma (H) - Before: Crystal Palace (A), After: Watford (H)
31 Oct: Roma (A) - Before: Bournemouth (A), After: Manchester United (H)
22 Nov: Qarabag (A) - Before: West Brom (A), After: LIverpool (A)
5 Dec: Atletico (H) - Before: Newcastle (H), After: West Ham (A)
Liverpool
13 Sept: Sevilla (H) - Before: Manchester City (A), After: Burnley (H)
26 Sept: Spartak (A) - Before: Leicester (A), After: Newcastle (A)
17 Oct: Maribor (A) - Before: Manchester United (H), After: Tottenham (A)
1 Nov: Maribor (H) - Before: Huddersfield (H), After: West Ham (A)
21 Nov: Sevilla (A) - Before: Southampton (H), After: Chelsea (H)
6 Dec: Spartak (H) - Before: Brighton (A), After: Everton (H)
Manchester City
13 Sept: Feyenoord (A) - Before: Liverpool (H), After: Watford (A)
26 Sept: Shakhtar (H) - Before: Crystal Palace (H), After: Chelsea (A)
17 Oct: Napoli (H) - Before: Stoke (H), After: Burnley (H)
1 Nov: Napoli (A) - Before: West Brom (A), After: Arsenal (H)
21 Nov: Feyenoord (H) - Before: Leicester (A), After: Huddersfield (A)
6 Dec: Shakhtar (A) - Before: West Ham (H), After: Manchester United (A)
Manchester United
12 Sept: Basel (H) - Before: Stoke (A), After: Everton (H)
27 Sept: CSKA (A) - Before: Southampton (A), After: Crystal Palace (H)
18 Oct: Benfica (A) - Before: Liverpool (A), After: Huddersfield (A)
31 Oct: Benfica (H) - Before: Tottenham (H), After: Chelsea (A)
22 Nov: Basel (A) - Before: Newcastle (H), After: Brighton: (A)
5 Dec: CSKA (H) - Before: Arsenal (A), After: Manchester City (H)
Tottenham
13 Sept: Dortmund (H) - Before: Everton (A), After: Swansea (H)
26 Sept: APOEL (A) - Before: West Ham (A), After: Huddersfield (A)
17 Oct: Real Madrid (A) - Before: Bournemouth (H), After: Liverpool (H)
1 Nov: Real Madrid (H) - Before: Manchester United (A), After: Crystal Palace (H)
21 Nov: Dortmund (A) - Before: Arsenal (A), After: West Brom (H)
6 Dec: APOEL (H) - Before: Watford (A), After: Stoke (H)