Liverpool forward Sadio Mane will miss the visit of Manchester United after being ruled out for six weeks with a hamstring problem sustained on international duty.
Philippe Coutinho is likely to be pushed forward to replace him with Emre Can coming back into midfield.
Midfielder Adam Lallana continued his recovery from a thigh strain in Qatar this week as he edges closer a comeback.
On Mane's injury, Jurgen Klopp said“Things like this happen. If you look around the world, a lot of players in this international break got injured.
“You always hope that nothing will happen, but as long as they are not around, we don’t know exactly what happens. It’s quite difficult to get in touch with all the different FAs and all that stuff like this.
“I had a chat immediately after the game with Sadio, how I always do with the boys. It was not clear it would be that serious, but he said ‘I feel something in my hamstring’, so it was clear it would be at least close for the United game - and now we know it’s much longer.
“That’s not cool, but we have to deal with it – how we always have to do.”
Provisional squad: Mignolet, Alexander-Arnold, Lovren, Matip, Moreno, Henderson, Can, Wijnaldum, Salah, Firmino, Coutinho, Karius, Gomez, Klavan, Grujic, Milner, Oxlade-Chamberlain, Sturridge, Solanke.