Everton take on Ligue 1 side Lyon at Goodison Park knowing defeat would all but end their hopes of reaching the knockout stages.
The Toffees have just one point from their opening two matches - a 3-0 thrashing at Atalanta and a disappointing 2-2 draw at home to Apollon Limassol.
Lyon have yet to pick up a win in Group H either, with two draws so far, meaning both sides are in desperate need of a victory.