Alderweireld missed most of Wednesday’s Champions League match against Real Madrid (Getty)

Tottenham have confirmed that both Hugo Lloris and Toby Alderweireld will miss Sunday’s Premier League match against Crystal Palace.

The duo both started against Real Madrid in Wednesday’s astonishing 3-1 victory over the defending European champions at Wembley Stadium.

However, Alderweireld was forced off with the scores still tied at the 24th minute-mark, clutching his thigh after bursting forward.

Lloris, meanwhile, took a heavy fall after punching clear a cross, though he did manage to finish the match despite Michel Vorm being sent to warm up.

It was expected that the duo would miss the game against Crystal Palace after they were omitted form their national team squads for the internal break, and Spurs have now confirmed the news.

Spurs tweeted: ‘Hugo (groin strain) and Alderweireld (hamstring strain) both unavailable and continue to undergo assessment.’

Lloris was omitted from the France squad due to the injury sustained against Real (Picture: Getty)

Tottenham will hope that their star pairing – who will undergo scans on Friday – can recover in time for the north London derby against Arsenal on Saturday 18 November.

Alderweireld’s injury is likely to see Eric Dier step back into defence against Palace (Picture: Getty)

They will have just over two weeks to recover over the course of the international fixtures, with the match against Arsenal the first game back after the break.

Meanwhile, Victor Wanyama – who has not played since taking on Chelsea in August – is continuing ‘fieldwork’ but will not be fit to take on Palace.