Harry Kane ruled out of Manchester United trip with hamstring injury in major blow to Tottenham Hotspur

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Tottenham have been dealt a massive blow ahead of their mouthwatering Premier League clash against Manchester United this weekend, with Harry Kane ruled out due to a hamstring strain.

Spurs revealed the news on Friday morning in a setback for the north London side's preparations as they look to move above United into second place.

They revealed he underwent assessment and investigation earlier this week, which confirmed a minor strain to the left hamstring. 

Tottenham star Harry Kane will miss their clash with Manchester United on Saturday 

Kane suffered the injury towards the end of Spurs' 4-1 win over Liverpool on Sunday

Spurs' star man grimaces and holds his hamstring after pulling up at Wembley

Tottenham boss Mauricio Pochettino revealed the news on Friday

Kane has been struggling with the injury sustained in Sunday's win over Liverpool.

'For tomorrow, we cannot take a risk,' manager Mauricio Pochettino said about Kane's fitness.

'It's a minor injury, very small, but we cannot take a risk. We'll see after for Wednesday versus Real Madrid. Tomorrow [Saturday] it's impossible. 

'Yes [it is a blow], you always want all the players available. It's a problem. To play more or play less, we want them available to play. We always believe in the collective, the squad. During the season, problems happen and you must trust all the players, all the squad. 

Spurs will have to alter their plan now due to the absence of the 24-year-old

Harry Winks and Georges-Kevin Nkoudou race against Jan Vertonghen in training on Thursday

Hugo Lloris (third from left) reacts as Tottenham's players joke around during the session

Vertonghen pokes the ball away as Spurs gear up to face Manchester United on Saturday

'I told the players they are not machines and it's so difficult to cope with international duty and to then play every three days. It's lucky it's not a big problem but he's not going to play tomorrow. 

'It makes no sense to take a risk when the problem is small and we can fix it in a few days probably.'  

It is a huge blow to Tottenham that their star striker cannot play against United, given his importance to Pochettino's team.

However, in his absence last season, Spurs were unbeaten in the seven Premier League matches Kane missed, winning five of them.

Kane has scored 13 goals in 12 appearances for Spurs this season.

Kane has scored 13 goals in 12 appearances for Tottenham in all competitions this season