It is Spurs’ first Premier League game at temporary home Wembley - a ground they struggled at in European competition last term - while Chelsea are desperate to avoid back-to-back defeats.
Merson believes both sides will be “nervous” and is predicting a stalemate.
“Chelsea won't lose here,” he said.
“I think both teams will be more than happy with a draw.
“You have to remember that the last thing Tottenham want to do is lose this game - their first at Wembley this season - and Chelsea can't afford to lose a second game on the bounce.
“Both teams will be nervous and I think it will be quite cagey.”
Tottenham kicked off their Premier League campaign with a 2-0 win at Newcastle while Chelsea suffered a shock 3-2 defeat at home to Burnley.
But Merson reckons Spurs were sub-par in their game, and says if there is a winner at Wembley then it will be Chelsea.
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“If not a draw I would probably go Chelsea,” he told Sky Sports.
“I was not impressed with Tottenham at Newcastle, I thought they were poor.”
