The Kop are hoping to ram home the advantage from the first leg of their Champions League qualifier in Germany.
They triumphed 2-1 and carry two precious away goals into tonight’s clash at Anfield.
Mohamed Salah is back in the starting line-up, however.
Andy Robertson drops to the bench and Alberto Moreno slots in at left back.
Joe Gomez, James Milner and Daniel Sturridge all drop to the bench.
Liverpool: Mignolet, Alexander-Arnold, Matip, Lovren, Moreno, Henderson, Can, Wijnaldum, Mane, Salah, Firmino.
Subs: Karius, Robertson, Klavan, Gomez, Milner, Sturridge, Solanke.
Hoffenheim: Baumann, Kaderabek, Nordveit, Hubner, Geiger, Vogt, Gnabry, Demirbay, Zuber, Kramaric, Wagner.
Subs: Kobel, Bicakcic, Rupp, Polanski, Toljan, Uth, Szalai.