Olivier Giroud leads the line for Arsenal with Jack Wilshere and Theo Walcott both starting as well.
The Gunners are without several top stars though.
Alexis Sanchez, Alexandre Lacazette, Sead Kolasinac, Mesut Ozil and Aaron Ramsey are all rested and not even in the squad for the trip to Belarus.
Speaking ahead of the match Arsene Wenger said: "I said on Monday that I would play an experienced team with a young bench - that's what I'll do.
"We have a tight schedule. It's an important game, only one or two young players will start.
"It's a good test for the young players. They will have to cope with that intimidating atmosphere. It will be very loud.
"Maitland-Niles' best position is central defensive midfielder," the Frenchman continued.
"He has great quality, he can steal the ball without making fouls. I believe he is ready to play. He has a great future."
Arsenal: Ospina, Holding, Mertesacker, Mustafi, Nelson, Willock, Elneny, Maitland-Niles, Walcott, Wilshere, Giroud
Subs: Macey, Dasilva, Gilmour, McGuane, Dragomir, Akpom, Mketiah
