The Reds face the unenviable task of spotting Jose Mourinho’s rampant United side, but must do so without star winger Sadio Mane.
The Senegalese ace has been ruled out for up to six weeks with hamstring injury sustained while on international duty with Senegal.
Long-term absentees Adam Lallana and Nathaniel Clyne are still unavailable while centre-back Dejan Lovren is a doubt.
Before the international break, Jurgen Klopp’s side were held to a disappointing 1-1 draw at Newcastle, so the manager will be desperate to bounce back with a win over the club’s biggest rivals.
Liverpool are currently seven points behind United in the Premier League table.
CLICK THROUGH THE GALLERY ABOVE TO SEE THE TEAM WE EXPECT TO START.
