The Red Devils go into the game in Lisbon having won both their games so far in the group stage.
Basel were beaten 3-0 at Old Trafford on matchday one, before CSKA Moscow were put to the sword 4-1 in Russia.
Benfica, in contrast, have been struggling massively, and were humiliated 5-0 away to Basel after already losing to CSKA.
With that in mind, Jose Mourinho is bound to be confident ahead of the game in his home country, and we are expecting him to make four changes to the side that drew 0-0 at Liverpool.
Midfield options are limited however, with Paul Pogba, Michael Carrick and Marouane Fellaini all injured - while Eric Bailly also has a problem and is unlikely to feature.
The game kicks off at 7.45pm on Wednesday evening, with Mourinho knowing three points would put his side on the verge of qualification for the knockout rounds.
CLICK THROUGH THE GALLERY ABOVE TO SEE HOW WE EXPECT UNITED TO SET UP AT THE ESTADIO DA LUZ IN LISBON.
