A flurry of late goals saw Manchester City extend their Premier League winning streak to 16 games as they beat Tottenham 4-1.
Pep Guardiola's side moved 14 points clear of Manchester United ahead of their trip to West Brom on Sunday.
Ilkay Gundogan opened the scoring on 14 minutes but they didn't add a second until the 70th minute through Kevin De Bruyne. Gabriel Jesus missed a penalty to make the points safe, before Raheem Sterling did just that scoring a late brace before Christian Eriksen's consolation goal in added time.
That result leaves Tottenham in seventh place, but only two points behind Arsenal in fourth.
Chelsea went level on points with second-placed Manchester United after seeing off Southampton 1-0 at Stamford Bridge.
The champions should have broken the deadlock with a quarter of an hour played when Willian, through on goal, steered his shot wide, and they threatened again when Fraser Forster saved from Gary Cahill.
Southampton, who lost Cedric Soares to injury, were in danger again when Willian miscued after Pedro had been unable to get to a cross and Tiemoue Bakayoko then saw an effort fly wide off a defender.
Chelsea were within a whisker of going in front when a Pedro shot was deflected against the post -- and just before the break they did so when Marcos Alonso curled a free kick low past Forster.
Thibaut Courtois made an excellent save to deny substitute Charlie Austin after the break, but Chelsea then thought they had scored a second only for Cesc Fabregas to be denied by an offside flag.
Mesut Ozil struck a spectacular winner for Arsenal as they defeated struggling Newcastle 1-0 at the Emirates.
Arsenal made a bright start and Newcastle keeper Rob Elliot saved Alexandre Lacazette's drive, with Lacazette having another effort deflected wide before 10 minutes had been played.
But Arsene Wenger's side had the lead they deserved after 23 minutes when Ozil fired an outstanding volley into the top corner after Newcastle had half-cleared, and Hector Bellerin fired a volley of his own high over as Arsenal continued to press.
Second-half substitute Matt Ritchie tried to get Newcastle going but saw his effort from the edge of the area fly over the top before Jack Wilshere saw his effort stopped by Rob Elliot -- but Newcastle kept going, and Joselu's shot hit Laurent Koscielny and bounced wide with Petr Cech stranded.
Stoke slumped to a fifth defeat in six to heap further pressure on Mark Hughes as West Ham's Marko Arnautovic came back to haunt his old club in a 3-0 win.
Chants of "Hughes Out" and "sacked in the morning" were heard from home supporters at the bet365 Stadium, where kick-off had been delayed by an hour due to a power cut.
Once proceedings got under way, David Moyes' West Ham were sent on their way by a controversially-awarded Mark Noble penalty, which could result in retrospective punishment for Manuel Lanzini after he appeared to dive, and Hughes' mood was darkened further by goals from Arnautovic and substitute Diafra Sakho.
It was particularly galling for Hughes that Arnautovic got on scoresheet given he was booed throughout having forced through a £25 million summer move to West Ham, who moved above Stoke in the table with this win.
Huddersfield got their first Premier League away win since the opening day of the season in a 4-1 triumph at Watford.
The visitors needed only five minutes to open the scoring as Elias Kachunga -- who appeared to be offside -- prodded home following a scramble.
Soon afterwards, Kachunga suffered a leg injury in a challenge with Watford keeper Heurelho Gomes and was stretchered off -- but that did not affect the visitors, who doubled their lead through Aaron Mooy.
The Hornets' tough task became even more difficult after 33 minutes when Troy Deeney was sent off for a rash challenge on Florent Hadergjonaj, and they were three goals down when Laurent Delpoitre struck early in the second period.
Huddersfield were also reduced to 10 men when Jonathan Hogg was sent off for a second bookable offence, and although Watford got one back when Abdoulaye Doucoure lashed home, Mooy rounded things off from the penalty spot late on.
Two fine first-half goals laid the foundations for Crystal Palace to win 3-0 at Leicester and move up to 14th in the Premier League.
Roy Hodgson's side looked the brighter from the early stages and led after 19 minutes when Christian Benteke headed home a whipped Andros Townsend cross from the right for their first away league goal of the season.
With five minutes remaining until half-time, Palace doubled their lead against an off-form home side who struggled to create clear-cut chances as Benteke picked out Wilfried Zaha, who thumped beyond Kasper Schmeichel.
Substitute Bakary Sako added a third in second-half stoppage time, soon after Schmeichel had made a near-post block from Benteke's close-range header.
In-form Burnley settled for a point after being on the back foot for long spells of their 0-0 draw at Brighton.
After a cagey start, Brighton began to exert some pressure with Lewis Dunk, up from defence for a free kick, seeing his shot ricochet to safety off a defender and striker Glenn Murray also going close.
Pascal Gross was thwarted by a fine stop from Nick Pope as the Seagulls looked the better side, and they should have taken the lead when Murray was adjudged to have been fouled by James Tarkowski inside the area only to fire a wild penalty high over the bar.
Burnley, who had failed to muster much threat in the first half, soon did so in the second when Chris Wood was denied by Brighton keeper Mat Ryan, and Ryan then made a fine double block before Wood turned the ball home but was ruled offside.