The boss has previously claimed wins at Goodison Park with Chelsea - but oversaw a 3-1 defeat for the Blues on Merseyside last season.
I had so many great matches there. Some I lost, some I won, but always a great match
Mourinho on Goodison Park
The stadium is the site of one of Portugal's greatest triumphs when they beat North Korea 5-3 in the 1966 World Cup quarter-finals, having at one stage been 3-0 down.
And Mourinho admits he is looking forward to being on the touchline this weekend.
GETTY
Portugal beat North Korea in the 1966 quarter-finals
GETTY
Eusebio returned to Goodison Park in 2009 to commemorate his four goals
Invalid email
We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You can unsubscribe at any time. Read our Privacy Policy
GETTY
Goodison Park was one of the main host stadiums during the 1966 World Cup
"I managed against (Roberto) Martinez’s Everton, (David) Moyes’ Everton and it is always difficult," Mourinho said.
"It is always beautiful with a great crowd and a great stadium which is historical for my country as Eusebio scored four goals in one match there during the World Cup in ‘66.
GETTY
Jose Mourinho (right) first managed at Everton when he was Chelsea boss in 2005
GETTY
Mourinho's Chelsea lost 3-1 at Everton last season
"I had so many great matches there. Some I lost, some I won, but always a great match.
"The way United is playing, combined with the way Everton always try to play means it should be a very good match.”
Everton can leapfrog United into sixth place in the Premier League if Ronald Koeman's men win on Sunday.
