Match odds
Pep Guardiola's men are the shortest price of any team in the top flight over the weekend. dabblebet go 2/15 (1.13) that City pick up maximum points on home soil, while the draw is available at 15/2 (8.50) and Newcastle are a massive 20/1 (21.0) to inflict back-to-back defeats on the hosts.
Rafael Benitez's side have won their previous two games away from home in the league, beating Stoke and West Ham by a single goal margin, but the Magpies face a huge step up in class here against the runaway leaders and their price reflects just what a task they have on their hands.
Predicted line-up
We asked Goal's Manchester City correspondent, Sam Lee, for his view on how Guardiola would set his team up for the game and it looks to be a full-strength line-up for the home side when taking their current injury list into account.
Gabriel Jesus, Benjamin Mendy and Vincent Kompany are still sidelined and Fabian Delph should fill in at left back again, whilst David Silva could return to midfield after being an unused substitute in the defeat to Liverpool.
Goal scorer prices
While backing Manchester City in accumulators might be a popular play, their extremely short match odds mean the goalscorer markets might provide punters with a better run for their money in terms of potential returns.
Raheem Sterling was the difference in a narrow 1-0 victory for City in the reverse fixture and the England international is 10/3 (4.33) to continue his impressive scoring season by breaking the deadlock in this game.
Sergio Aguero is favourite at 2/1 (3.0) with dabblebet, who are 4/1 (5.0) on Leroy Sane, who should complete the hosts' front three, notching the first goal of the match.
Kevin De Bruyne is 6/5 (2.20) to find the net anytime, while it's 8/5 (2.60) about David Silva find the back of the net during the 90 minutes at the Etihad.
Joselu was on target in Newcastle's 1-1 draw with Swansea last time out and he's 16/1 (17.0) to score first here or 7/2 (4.50) anytime. Ayoze Perez fired in the winner against Stoke for the Magpies and it's 16/1 (17.0) that he opens the scoring in Manchester.