Harry Kane has been ruled out of Tottenham's clash with Manchester United tomorrow.
The striker has suffered a hamstring strain and could also miss next week's Champions League tie against Real Madrid.
Kane had been undergoing intensive treatment but it proved to be a losing battle.
He has been the spearhead of Spurs challenge in the Premier League and the Champions League.
But Kane was left out of the squad for Wednesday night's Carabao Cup defeat to West Ham and it appears Fernando Llorente will lead the line against United.
Spurs boss Mauricio Pochettino said: "For me, we cannot take a risk. It is very small but we cannot take a risk for tomorrow.
"We will see for Real Madrid on Wednesday. Always you want to have all your players available. Always it is a problem. But like always we believe in our squad.”
Pep Guardiola incensed Pochettino by referring to Tottenham as the “Harry Kane team” earlier this month.
Beating title rivals Manchester United away is a chance to prove they are not.
But the Spurs boss said: “We don't need to prove ourselves that we're Tottenham. Maybe people expect that but for us, no! Last season, when he was injured, you can see the stats, the games we played.
"We didn't lose without Harry or with Harry! I'm not happy, I'm disappointed because Harry is our main striker and one of the best strikers in the world. You're always going to miss your best striker. I'm not stupid."