Antonio Conte has decided to bench both Eden Hazard and Diego Costa for Chelsea's huge FA Cup semi-final clash against Spurs.
It's a big gamble from the Italian, who has decided to start Michy Batshuayi and Willian instead.
Gary Cahill is also missing after the Blues confirmed he was being treated for gastroenteritis on Friday. Nathan Ake is starting in the England international's place.
Marcos Alonso returns after missing Chelsea's last game through illness.
For Spurs, Hugo Lloris makes his first FA Cup start since 2014 as Michel Vorm is ruled out with a knee injury.
Despite Danny Rose returning to Tottenham training this week, the 26-year-old is still not fit enough for a place on the subs bench.
Kieran Trippier starts at right-back for the north Londoners in place of Kyle Walker.
It's a case of first versus second at Wembley on Saturday afternoon. A victory for either side will not only give them an extra chance of silverware this season, but a mental edge in the Premier League title chase.
In the previous round, Chelsea edged past a 10-men Manchester United, while Spurs battered League One Millwall 6-0.
The winner of this tie will face either Arsenal or Manchester City in the final - who are playing tomorrow.
Chelsea line-up: Courtois; Azpilicueta (C), David Luiz, Ake; Moses, Kante, Matic, Alonso; Willian, Batshuayi, Pedro.
Subs: Begovic, Zouma, Terry, Chalobah, Fabregas, Hazard, Diego Costa.
Spurs line-up: Lloris (C), Trippier, Dier, Alderweireld, Vertonghen, Wanyama, Dembele, Son, Eriksen, Dele, Kane.
Subs: Lopez, Davies, Walker, Wimmer, Sissoko, Nkoudou, Janssen.