Alvaro Morata is expected to start following a hamstring injury when Chelsea play Roma in Champions League Group C on Wednesday night.
But right wing-back Victor Moses is to join midfielder N'Golo Kante in being absent with a hamstring injury.
Midfielder Danny Drinkwater (calf) remains sidelined, so Chelsea may play Davide Zappacosta in place of Moses and could push David Luiz or his fellow defender Andreas Christensen into midfield.
Boss Antonio Conte said: "When there are injuries of this type, it's very difficult for us. This is the situation and we must overcome it and try to do our best," he told a news conference on Tuesday.
"The problem is that the same players are always playing. In our team we have players not used to playing three games in a row. For Kante it's the first time, for Moses it's the same.
"For Morata it's the first time he will play with this team. When you have a lot of games you need to protect players. If this isn't possible I have to take a risk."
Provisional squad: Courtois, Caballero, Rudiger, Alonso, Fabregas, Morata, Hazard, Pedro, Bakayoko, Kenedy, Musonda, Zappacosta, Willian, Batshuayi, Cahill, Christensen, Azpilicueta, Clarke-Salter, Scott, Eduardo, Ampadu, Sterling.