Jose Mourinho has admitted he has "no idea" when star midfielder Paul Pogba will return from injury.
The Frenchman was originally thought to be facing six weeks on the sidelines after suffering a hamstring injury against Basel but it now sounds as though he could be out for even longer.
Speaking ahead of Manchester United's clash with Southampton on Saturday, Mourinho said Pogba's return date was unknown but added he was not going to sit around 'crying' about the situation.
"I have no idea when he [Pogba] will be back, no idea, but again, this is a great opportunity for other players to play and I trust them all," said Mourinho.
"I'm not going to cry or be counting the days until Pogba comes back. When he comes back, welcome, but until then I trust my people."
Marcos Rojo, Zlatan Ibrahimovic (both knee)and Axel Tuanzebe (back) are all also absent for the trip to St Mary's.
Luke Shaw is hoping to be involved against his former club having returned from injury as a substitute in the Carabao Cup win against Burton. David de Gea, Antonio Valencia, Eric Bailly and Nemanja Matic are set to be involved after being rested for Wednesday's match.
Provisional squad: De Gea, Romero, Pereira, Valencia, Darmian, Lindelof, Bailly, Jones, Smalling, Blind, Shaw, Young, Fellaini, Matic, Herrera, Carrick, McTominay, Mata, Lingard, Mkhitaryan, Lukaku, Rashford, Martial.