Manchester United will be hoping to put a dent in Manchester City's title hopes when the pair face off in a blockbuster clash at Old Trafford.
Jose Mourinho's troops are currently eight points behind the league leaders and should they lose to their rivals the title race could be over by Christmas.
United come into the clash following an impressive away win over Arsenal and a 2-1 win Champions League victory over CSKA Moscow.
City, however, will be looking top bounce back from their first defeat of the season having lost to Shakhtar Donetsk in the Champions League on Wednesday.
But with the Red Devils unbeaten in a record 40 matches at Old Trafford under Mourinho, this will be no easy task for Kevin De Bruyne and co.
When is the match?
Manchester United vs Manchester City will kick-off at 4.30pm on Sunday December 10 at Old Trafford.
Which channel is the match on?
The Manchester derby will be shown on Sky Sports Main Event at 4.15pm with coverage following on from Liverpool's clash against Everton.
Is there a live stream of the match?
You can watch United's clash against their rivals via the Sky Go app and website.
If you do not have a Sky Sports subscription, you can also follow the action live on Mirror Football.
Manchester United team news
Jose Mourinho has been handed a triple injury boost going into the tie, with Zlatan Ibrahimovic, Phil Jones and Marouane Fellaini all available.
Speaking ahead of the clash, the United boss added: "Michael Carrick is not available, Eric Bailly is not available. Nemanja Matic is injured but he plays."
Paul Pogba is of course suspended following his red card against Arsenal last weekend.
Manchester City team news
City have been handed a boost of their own as David Silva has been given the green light to play. The Spaniard, who is arguably in the form of his life, was a doubt heading into the derby.
Vincent Kompany could be out again too after he "felt something" ahead of the Shakhtar Donetsk clash.
While Fabian Delph is suffering from a sickness bug.
Betting odds
According to Betfair...
Manchester United win - 12/5
Manchester City win - 13/5
Draw - 6/5