Alexis Sanchez and his new teammates jetted out of Manchester on Friday morning ahead of their FA Cup clash with Yeovil.
The Red Devils are in fourth round action against the League Two side at Huish Park.
Sanchez, who completed his move from Arsenal earlier this week, will be involved although it is unclear if he will start.
Jose Mourinho said: "You know, because he's been in England for quite a long time, I think everybody knows the player he is.
"I think everybody knows what he did at Arsenal."
I try not to speak what he did before in Spain and Italy, but in the Premier League he's shown the quality he has.
"We got one of the best attacking players in the world and he's very important for us because we ant the best possible players.
Mourinho has promised to play a "very strong team" but conceded some players will be rested, with Sergio Romero likely to replace David De Gea in goal as he did in the last round.
Marcus Rashford is also likely to come back in and Scott McTominay may get a start, while youngster Angel Gomes has travelled.
Zlatan Ibrahimovic (knee) and Eric Bailly (ankle) remain sidelined by injury while Axel Tuanzebe joined Aston Villa on loan on Thursday.
Provisional teams
Yeovil: Krysiak, Mugabi, James, Smith, Dickson, Gray, Green, Gobern, Bird, Surridge, Zoko.
Man Utd: Romero; Darmian, Smalling, Rojo, Shaw; McTominay, Herrera; Mata, Lingard, Rashford; Lukaku